Bleomycin Injection

Bleomycin Injection Specification

Salt Composition
Bleomycin Sulphate

Dosage Form
Injection

Indication
Used in the treatment of cancer (such as Hodgkins lymphoma, testicular cancer, squamous cell carcinomas, etc.)

Enzyme Types
Glycopeptide Antibiotic (Not an enzyme, but classified for antimicrobial use)

Feature
Lyophilized powder for reconstitution, potent antineoplastic activity

Ingredients
Bleomycin Sulphate as active ingredient, sterile excipients

Application

Ph Level
6.57.5

Temperature Needed For Fermentation
Usually produced by fermentation with Streptomyces verticillus at 2830C (for bulk API manufacturing)

Physical Color/Texture
White or pale yellow powder

Fermentation Smell
Characteristic faint odor

Enzymatic Activity
Not applicable (acts as a chemotherapeutic agent; not used for its enzymatic activity)

Storage Instructions
Store below 25C, protect from light. Reconstituted solution should be used immediately or stored below 8C for up to 24 hours.

Shelf Life
23 years (unopened vial)

ATC Code
L01DC01

Route of Administration
Intravenous (IV), Intramuscular (IM), Subcutaneous (SC), Intra-pleural

Reconstitution Solvent
Sterile Water for Injection

Purity
>95% (Pharmaceutical Grade)

Prescription
Prescription Only

Strength
15 Units/Vial (International Units)

Molecular Weight
approximately 1500 Da (varies by Bleomycin fraction)

CAS Number
9041-93-4

Warning
For hospital use only, potential for pulmonary toxicity

Packaging Type
Glass Vial with flip-off seal

About Bleomycin Injection

Bleomycin Injection:-

Dosage and Indication

Intramuscular
Lymphoma
Adult: 15,000 IU once or twice a wk, up to a total cumulative dose of 225,000 IU.
Elderly: Dose reduction is necessary.
Renal impairment: Dose reduction is necessary.
Parenteral

Squamous cell or testicular tumours
Adult: 15,000 IU 3 times a wk or 30,000 IU twice a wk IM/IV, repeated at usual intervals of 3-4 wk up to a total cumulative dose of 500,000 IU.
Elderly: Dose reduction is necessary.
Renal impairment: Dose reduction is necessary.
Injection

Malignant effusions
Adult: 60,000 IU in 100 ml of 0.9% sodium chloride instilled into the affected serous cavity, may be repeated up to a total cumulative dose of 500,000 IU.
Elderly: Dose reduction is necessary.
Renal impairment: Dose reduction is necessary.

Comprehensive Cancer Treatment

Bleomycin Injection provides broad-spectrum anticancer efficacy, targeting several malignancies such as Hodgkins lymphoma, testicular cancer, and specific squamous cell carcinomas. By disrupting cancer cell replication, it aids in effective disease management under supervised clinical settings.

Versatile Administration & Packaging

Available as a lyophilized powder in a glass vial with a flip-off seal, this formulation allows for multiple routes of administration, including intravenous, intramuscular, subcutaneous, and intra-pleural. Its flexible delivery optimizes therapeutic protocols tailored to patient needs.

Strict Hospital Use & Storage Guidelines

For safety, Bleomycin Injection is only for hospital use, administered by healthcare professionals. Following reconstitution with sterile water, the solution should be used promptly or stored below 8C for up to 24 hours, ensuring maximum stability and efficacy.

FAQs of Bleomycin Injection:

Q: How should Bleomycin Injection 15 Units/Vial be reconstituted and administered?

A: The lyophilized powder should be reconstituted with sterile water for injection. Administration routeintravenous, intramuscular, subcutaneous, or intra-pleuraldepends on your doctors protocol and cancer type. Only qualified healthcare professionals should handle preparation and administration.

Q: What types of cancer are most commonly treated with Bleomycin Injection?

A: Bleomycin is indicated mainly for the treatment of cancers such as Hodgkins lymphoma, testicular cancer, and various squamous cell carcinomas. Your oncologist will determine its suitability based on your diagnosis.

Q: When and how long after reconstitution can Bleomycin Injection be used?

A: After reconstitution, the solution should be used immediately for best results. If not used at once, it may be stored below 8C and must be used within 24 hours to maintain potency and safety.

Q: Where should Bleomycin Injection vials be stored before use?

A: Store unopened vials below 25C in a dry place protected from light. Once reconstituted, keep the solution below 8C and strictly follow the expiration and handling guidelines to ensure safety.

Q: What is the benefit of using Bleomycin Injection in cancer therapy?

A: Bleomycin offers potent antineoplastic activity, disrupting cancer cell DNA and contributing to comprehensive cancer treatment plans. Its multi-route administration and high efficacy make it a valuable option in hospital oncology regimens.

Q: What precautions and warnings should be considered with Bleomycin Injection?

A: Due to potential pulmonary toxicity, Bleomycin must be used strictly in a hospital setting under medical supervision. Regular lung function monitoring and adherence to prescribed dosages are crucial during treatment.

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