Adriamycin - Doxorubicin Injection

Adriamycin - Doxorubicin Injection Specification

Salt Composition
Doxorubicin Hydrochloride

Dosage Form
Injection

Indication
Antineoplastic agent; indicated for treatment of various cancers including breast cancer, lymphomas, sarcomas, and leukemias

Feature
Cytotoxic antibiotic; broad spectrum anti-cancer activity; potent DNA intercalator

Ingredients
Doxorubicin Hydrochloride, excipients (including lactose, sodium chloride, water for injection)

Application
Intravenous administration

Ph Level
Approximately 4.0 to 5.0

Physical Color/Texture
Red, clear solution

Fermentation Smell
Odorless

Storage Instructions
Store between 2C to 8C, protect from light

Shelf Life
24 months from date of manufacture

Therapeutic Category
Anthracycline antineoplastic

Strength
10 mg/5 ml, 50 mg/25 ml (available vial strengths)

CAS Number
23214-92-8

Contraindications
Known hypersensitivity to doxorubicin or other anthracyclines

Molecular Weight
543.52 g/mol

Administration Route
Intravenous infusion

Molecular Formula
C27H29NO11

Precautions
Use under direct supervision of a healthcare professional; monitor cardiac function

Packaging Type
Sterile glass vials with flip-off cap

Batch Number Format
Alphanumeric code on vial label

About Adriamycin - Doxorubicin Injection

Adriamycin - Doxorubicin Injection:-

Packing: 5ML Vial

This medicine is an antineoplastic antibiotic used to treat certain types of cancer.

Before Using This Medicine: WARNING: This medicine must be given slowly and directly into a vein (IV) through other intravenous (IV) fluids. Do not inject this medicine into the muscle (IM) or just beneath the skin (subcutaneously). If this medicine accidentally leaks into surrounding tissue, the skin and/or muscle may be severely damaged. Notify the doctor immediately if redness, pain, or swelling occur at (or around) the injection site. Doxorubicin may cause heart problems (including heart failure) or bone marrow suppression. Notify your doctor immediately if you develop an irregular heartbeat, trouble breathing, swelling of the hands or feet, easy bruising or bleeding, dry cough, or signs of infection such as fever, unusual fatigue, or persistent sore throat. Heart problems may occur during therapy or sometimes, months to years after receiving this medicine. The risk of developing heart problems varies depending on your dose and condition. Tell your doctor if you have liver problems since the dose should be decreased in this situation. Your doctor will closely monitor you while you are using this medicine. Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking cyclosporine, cyclophosphamide, digoxin, warfarin, or medicine for seizures. Inform your doctor of any other medical conditions, allergies, pregnancy, or breast-feeding. Contact your doctor or pharmacist if you have any questions or concerns about taking this medicine.

Mechanism and Therapeutic Benefits

Doxorubicin works by intercalating DNA, disrupting cellular replication and effectively inhibiting cancer cell growth. Its broad-spectrum anti-cancer properties make it suitable for treating a variety of malignancies, including breast cancer, lymphomas, and leukemias, under specialized oncological care.

Packaging and Composition Details

Each sterile glass vial contains either 10 mg/5 ml or 50 mg/25 ml of doxorubicin hydrochloride, dissolved with lactose, sodium chloride, and water for injection. The solution appears red and clear and is odorless, ensuring reliable quality and accurate dosing every time.

Storage and Handling Instructions

For optimal stability, store Adriamycin vials between 2C to 8C, avoiding exposure to light. Handle all cytotoxic drugs with protective equipment and observe all safety protocols. The shelf life of unopened vials is 24 months from the manufacturing date, as indicated on the label.

FAQs of Adriamycin - Doxorubicin Injection:

Q: How is Adriamycin (Doxorubicin Injection) administered safely?

A: Adriamycin is strictly administered as an intravenous infusion by healthcare professionals. Cardiac function should be monitored throughout the treatment due to the risk of cardiotoxicity. Use only in a controlled clinical setting.

Q: What types of cancers is Adriamycin indicated for?

A: Adriamycin is used to treat a range of cancers, including breast cancer, various lymphomas, sarcomas, and leukemias. Its efficacy spans several malignant disease types, as determined by the prescribing oncologist.

Q: When should Adriamycin not be used?

A: Adriamycin is contraindicated in patients with known hypersensitivity to doxorubicin, other anthracyclines, or any of its components. Contraindications must be reviewed prior to prescribing.

Q: Where should Adriamycin vials be stored to maintain stability?

A: Store Adriamycin vials in a refrigerator at temperatures between 2C and 8C, protected from light to preserve effectiveness and prevent degradation.

Q: What precautions are necessary during Adriamycin infusion?

A: Infusion requires direct medical supervision, protective equipment during handling, and regular monitoring of cardiac function and blood counts to promptly manage potential side effects.

Q: What are the benefits of using Adriamycin in cancer therapy?

A: Adriamycin offers robust anti-cancer activity due to its DNA intercalation mechanism, resulting in potent cytotoxic effects and broad-spectrum efficacy across multiple cancers.

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